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Competing Interests The authors declare that they have no competing interests Materials and Methods Plasmid construction Amino acids mutations to switch Rex-domain specificity from NAD to NADP were selected based on a previous screen [15]

4.1.3 FOXO regulators FOXO transcription factors play a crucial role in the human body [126]

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### Step 8: Label and Refrigerate Immediately write on the vial: - Reconstitution date - Concentration (e.g., "5mg/mL") - Use-by date (28 days from today) Place in the refrigerator within 5 minutes of reconstitution